Delivery of chemotherapeutic drugs in tumour cell-derived microparticles

Author: Tang, K.; Zhang, Y.; Zhang, H.; Xu, P.; Liu, J.; Ma, J.; Lv, M.; Li, D.; Katirai, F.; Shen, G.-X.; Zhang, G.; Feng, Z.-H.; Ye, D.; Huang, B. Description: Cellular microparticles are vesicular plasma membrane fragments with a diameter of 100-1,000 nanometres that are shed by cells in response to various physiological and artificial stimuli. Here we demonstrate that tumour cell-derived microparticles can be used as vectors to deliver chemotherapeutic drugs. We show that tumour cells incubated with chemotherapeutic drugs package these drugs into microparticles, which can be collected…

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Efficacy of Listerine, Meridol and chlorhexidine mouthrinses on plaque, gingivitis and plaque bacteria vitality

Author: Brecx, M.; Netuschil, L.; Reichert, B.; Schreil, G. Description: The experimental gingivitis model was used to compare the anti-plaque, anti-gingivitis and anti-microbial efficacies of a phenolic compound (Listerine) and an amine/stannous fluoride mouthwash (Meridol), using a placebo preparation as negative control and a chlorhexidine solution as positive control in a double-blind study. After professional toothcleaning, 36 volunteers performed optimal oral hygiene for a period of 2 weeks. They then ceased all oral hygiene procedures for 21 days during which they rinsed twice daily with 1 of the 4 mouthrinses….

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Resistance training enhances muscular performance in patients with anorexia nervosa: a randomized controlled trial

Author: Fernandez-del-Valle, M.; Larumbe-Zabala, E.; Villasenor-Montarroso, A.; Cardona Gonzalez, C.; Diez-Vega, I.; Lopez Mojares, L.M.; Perez Ruiz, M. Description: OBJECTIVE: Low-intensity exercise applied in anorexia nervosa patients has been shown to have a harmless effect on body composition and to effect short-term improvements in muscular strength and agility. The aim of this study was to determine the effects of a high-intensity resistance training program designed for adolescents to improve strength and agility in anorexia nervosa restricting-type patients (AN-R). METHODS: From a total of 36 female patients with AN-R, one group…

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Does Classical Music Relieve Math Anxiety? Role of Tempo on Price Computation Avoidance: MATH ANXIETY AND MUSIC TEMPO

Author: Feng, S.; Suri, R.; Bell, M. Description: Marketers often do not present prices in ways that permit easy comparisons or calculations. For many consumers, situations that involve numbers and computations lead to math anxiety. Results of three studies show that math-anxious consumers tend to avoid alternatives that require price computations. Interestingly, such consumers find relief from math anxiety when slow tempo classical music plays in the background. However, in the absence of background music or when the tempo of such music is fast, those with high math anxiety exhibited…

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Leaf Senescence: Correlated with Increased Levels of Membrane Permeability and Lipid Peroxidation, and Decreased Levels of Superoxide Dismutase and Catalase

Author: Dhindsa, R.S.; Plumb-Dhindsa, P.; Thorpe, T.A. Description: The changes in membrane permeability (soluble leakage), lipid peroxidation, and activities of superoxide dismutase (SOD) and catalase have been studied during in situ senescence of leaves of Nicotiana tabacum L., cv. Wisconsin 38. After full leaf expansion was reached there was a rapid, almost linear increase in the rate of 86Rb leakage from the preloaded leaf discs, with leaf age. Parallel with this increase in membrane permeability was a cumulative increase in the level of lipid peroxidation. At the same leaf age…

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Setting the tone with the tune: A meta-analytic review of the effects of background music in retail settings

Author: Garlin, F.V.; Owen, K. Description: Among the many in-store elements purported to impact patrons, background music is a leading feature of academic enquiry [Turley LW, Milliman RE. Atmospheric Effects on Shopping Behavior: A Review of the Experimental Evidence. J Bus Res 2000;49(2):193–211.]. Collectively, research examines a range of retail contexts, focuses on many different dimensions, and, uses different methods to explore the phenomena of background music in commercial settings. Therefore, conclusions are difficult on the extent to which the influences of background music on customer behavior are generalizable. The…

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Mercury speciation in surface and deep waters of the Mediterranean Sea

Author: Kotnik, J.; Horvat, M.; Tessier, E.; Ogrinc, N.; Monperrus, M.; Amouroux, D.; Fajon, V.; Gibicar, D.; Zizek, S.; Sprovieri, F.; Pirrone, N. Description: Mercury speciation and its distribution in surface and deep waters of the Mediterranean Sea were studied during two oceanographic cruises on board the Italian research vessel URANIA in summer 2003 and spring 2004 as part of the Med Oceaneor and MERCYMS projects. The study included deep water profiles of dissolved gaseous Hg (DGM), reactive Hg (RHg), total Hg (THg), monomethyl Hg (MeHg) and dimethyl Hg (DMeHg)…

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Breakdown of dietary restraint following mere exposure to food stimuli: Interrelationships between restraint, hunger, salivation, and food intake

Author: Rogers, P.J.; Hill, A.J. Description: It was hypothesised that the hunger-enhancing effects of exposure to the sight and smell of palatable food would disinhibit eating in restrained eaters (self-reported dieters). In two experiments exposure to palatable food stimuli led to increases in motivational (hunger) ratings and salivation, and was followed by overeating in restrained subjects compared with the control condition (no food during exposure) and a condition in which nonpreferred food was presented during the exposure phase. The food intake of unrestrained subjects, on the other hand, was reduced…

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Effects of the availability of rewarding septal and hypothalamic stimulation on bar pressing for food under conditions of deprivation

Author: Routtenberg, A.; Lindy, J. Description: 10 rats with electrodes aimed at medial forebrain bundle-posterior hypothalamus (MFB), and 4 rats with electrodes aimed at septal area were trained to press for food for 1 hr/day. Food was available only during this session. After stable weight levels were demonstrated, rewarding brain stimulation was made available during the 1-hr feeding session. All septal Ss and 4 hypothalamic Ss maintained their weight on this regimen. The other 6 hypothalamic Ss essentially ignored food, spending most of the session self-stimulating, and “self-starved.” Self-starving Ss…

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The impact of Stereotype Threat on the simulated driving performance of older drivers

Author: Joanisse, M.; Gagnon, S.; Voloaca, M. Description: Older drivers are perceived as being dangerous and overly cautious by other drivers. We tested the hypothesis that this negative stereotype has a direct influence on the performance of older drivers. Based on the Stereotype Threat literature, we predicted that older driving performance would be altered after exposure to a Stereotype Threat. Sixty-one older drivers aged 65 and above completed a simulated driving assessment course. Prior to testing, half of the participants were told that the objective of the study was to…

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