Author: Mandinova, Anna; Lee, Sam W.
Description: A large fraction of human tumors carry p53 mutations, which allow tumor initiation and progression; furthermore, it is now clear that restoration or reactivation of wild-type p53 function prompts rapid elimination of tumors. The discovery and design of compounds that reactivate or enhance the p53 pathway has resulted in the identification of promising drug candidates that have now entered clinical trials for anticancer strategies. However, some of these agents appear to elicit undesirable toxic effects on normal cells and tissues and therefore are restricted in the dose that can be applied in tumors. In this Review, we discuss the concerns about and promise of these p53 activators and propose ways to expand and optimize screening strategies to identify such molecules.
Subject headings: Antineoplastic Agents; Humans; Models, Biological; Neoplasms; Signal Transduction; Tumor Suppressor Protein p53
Publication year: 2011
Journal or book title: Science Translational Medicine
Volume: 3
Issue: 64
Pages: 64rv1
Find the full text: https://www.strategian.com/fulltext/Mandinova2011.pdf
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Serial number: 4016