Author: Bah, Thierno M.; Goodman, James; Iliff, Jeffrey J.
Description: Sleep is a behavioral phenomenon conserved among mammals and some invertebrates, yet the biological functions of sleep are still being elucidated. In humans, sleep time becomes shorter, more fragmented, and of poorer quality with advancing age. Epidemiologically, the development of age-related neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease is associated with pronounced sleep disruption, whereas emerging mechanistic studies suggest that sleep disruption may be causally linked to neurodegenerative pathology, suggesting that sleep may represent a key therapeutic target in the prevention of these conditions. In this review, we discuss the physiology of sleep, the pathophysiology of neurodegenerative disease, and the current literature supporting the relationship between sleep, aging, and neurodegenerative disease.
Subject headings: Aging; Animals; Brain; Humans; Neurodegenerative Diseases; Sleep; Alzheimer disease; Cognitive decline; Dementia; Treatment.
Publication year: 2019
Journal or book title: Neurotherapeutics: The Journal of the American Society for Experimental NeuroTherapeutics
Volume: 16
Issue: 3
Pages: 554-568
Find the full text: https://www.strategian.com/fulltext/Bah2019.pdf
Find more like this one (cited by): https://scholar.google.com/scholar?cites=13987180666446302738&as_sdt=1000005&sciodt=1,16&hl=en
Serial number: 4073
One comment