the floor on a movable platform with casters.
Author: Walf, AA; Frye, CA
Description: The elevated plus maze is a widely used behavioral assay for rodents and it has been validated to assess the anti-anxiety effects of pharmacological agents and steroid hormones, and to define brain regions and mechanisms underlying anxiety-related behavior. Briefly, rats or mice are placed at the junction of the four arms of the maze, facing an open arm, and entries/duration in each arm are recorded by a video-tracking system and observer simultaneously for 5 min. Other ethological parameters (i.e., rears, head dips and stretched-attend postures) can also be observed. An increase in open arm activity (duration and/or entries) reflects anti-anxiety behavior. In our laboratory, rats or mice are exposed to the plus maze on one occasion; thus, results can be obtained in 5 min per rodent.
Subject headings: Animals; Anxiety; Data Collection/methods; Exploratory Behavior/physiology; Mice; Observation; Rats
Publication year: 2007
Journal or book title: Nature protocols
Volume: 2
Issue: 2
Pages: 322-328
Find the full text: https://www.strategian.com/fulltext/Walf2007.pdf
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Serial number: 4215