Microwave assisted synthesis of the fragrant compound Calone 1951®

Drevermann, B., Lingham, A., Hügel, H., Marriott, P. (2005)

Tetrahedron Letters, 46(1), 39-41

Calone 1951®, 7-methyl-benzo[b][1,4]dioxepin-3-one, possesses a strong marine, ozone note with floral nuances and is synthesised via a three-step procedure using microwave irradiation. High yields were obtained, and reaction times reduced to a few minutes, allowing for an efficient and inexpensive synthesis of Calone 1951®.

Microwave irradiation has been utilized in a three-step synthetic route to the fragrant compound, 7-methyl-benzo[b][1,4]dioxepin-3-one, commercially known as Calone 1951®. The use of a microwave reactor increases the simplicity and efficiency of the overall synthesis.

Subject headings: Calone 1951®; Fragrant compound; Microwave irradiation

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Type: Journal Article

Serial number: 724