Author: Choi, D.L.; Davis, J.F.; Fitzgerald, M.E.; Benoit, S.C.
Description: Consumption beyond homeostatic needs, referred to here as reward-based feeding behavior, is a central contributor to the current obesity epidemic worldwide. Importantly, reward-based feeding can be driven by palatability, the taste and texture of the food, as well as cues associated with the consumption of palatable foods. The hypothalamic orexin system regulates both diet preference and anticipation of food rewards making it a likely target to modulate reward-based feeding behavior. In the current manuscript, we hypothesized that orexin signaling mediates food-motivated behaviors and reward-based feeding behavior. We further hypothesized that orexin neurons and targets of the orexin system become activated in response to cues associated with the consumption of palatable food. Data from these studies suggest that orexin signaling promotes progressive ratio responding for palatable foods while blockade of orexin signaling attenuates reward-based feeding of a high fat diet. In addition, cues linked to the consumption of chocolate, or the receipt of a daily meal, activate the orexin system and its target regions differentially. Collectively, these data suggest that orexin signaling mediates reward-based feeding behavior and, within specific target regions, may regulate cue-induced overconsumption of palatable foods.
Subject headings: Animals; Benzoxazoles/pharmacology; Brain/drug effects/physiology; Cacao; Central Nervous System Agents/pharmacology; Cues; Dietary Fats; Eating/drug effects/physiology; Feeding Behavior/drug effects/physiology; Food; Intracellular Signaling Peptides and Proteins/metabolism; Male; Motivation/drug effects/physiology; Neurons/drug effects/physiology; Neuropeptides/metabolism; Orexin Receptors; Orexins; Rats; Rats, Long-Evans; Receptors, G-Protein-Coupled/antagonists & inhibitors/metabolism; Receptors, Neuropeptide/antagonists & inhibitors/metabolism; Reward; Urea/analogs & derivatives/pharmacology; Obesity
Publication year: 2010
Journal or book title: Neuroscience
Volume: 167
Issue: 1
Pages: 11-20
Find the full text : http://www.sciencedirect.com/science/article/pii/S0306452210001582
Find more like this one (cited by): https://scholar.google.com/scholar?cites=11877148179755405764&as_sdt=1000005&sciodt=0,16&hl=en
Type: Journal Article
Serial number: 1324