Author: Frank, G.K.; Bailer, U.F.; Henry, S.E.; Drevets, W.; Meltzer, C.C.; Price, J.C.; Mathis, C.A.; Wagner, A.; Hoge, J.; Ziolko, S.; Barbarich-Marsteller, N.; Weissfeld, L.; Kaye, W.H.
Description: BACKGROUND: Several lines of evidence support the possibility that disturbances of dopamine (DA) function could contribute to alterations of weight, feeding, motor activity, and reward in anorexia nervosa (AN).
METHODS: To assess possibly trait-related disturbances but avoid confounding effects of malnutrition, 10 women who were recovered from AN (REC AN) were compared with 12 healthy control women (CW). Positron emission tomography with [(11)C]raclopride was used to assess DA D2/D3 receptor binding.
RESULTS: The women who were recovered from AN had significantly higher [(11)C]raclopride binding potential in the antero-ventral striatum than CW. For REC AN, [(11)C]raclopride binding potential was positively related to harm avoidance in the dorsal caudate and dorsal putamen.
CONCLUSIONS: These data lend support for the possibility that decreased intrasynaptic DA concentration or increased D2/D3 receptor density or affinity is associated with AN and might contribute to the characteristic harm avoidance or increased physical activity found in AN. Most intriguing is the possibility that individuals with AN might have a DA related disturbance of reward mechanisms contributing to altered hedonics of feeding behavior and their ascetic, anhedonic temperament.
Subject headings: Adult; Algorithms; Anorexia/metabolism/psychology/radionuclide imaging; Dopamine Antagonists/diagnostic use; Female; Humans; Magnetic Resonance Imaging; Neostriatum/radionuclide imaging; Nucleus Accumbens/radionuclide imaging; Positron-Emission Tomography; Raclopride/diagnostic use; Receptors, Dopamine D2/metabolism; Receptors, Dopamine D3/metabolism; Reward
Publication year: 2005
Journal or book title: Biological Psychiatry
Volume: 58
Issue: 11
Pages: 908-912
Find the full text: http://eatingdisorders.ucsd.edu/research/pub/imaging/doc/2005/frank2005increased.pdf
Find more like this one (cited by): https://scholar.google.com/scholar?cites=10437973357750096872&as_sdt=1000005&sciodt=0,16&hl=en
Type: Journal Article
Serial number: 90