Author: Cabiscol, E.; Tamarit, J.; Ros, J.
Description: The advent of O2 in the atmosphere was among the first major pollution events occurred on earth. The reaction between ferrous iron, very abundant in the reductive early atmosphere, and oxygen results in the formation of harmful superoxide and hydroxyl radicals, which affect all macromolecules (DNA, lipids and proteins). Living organisms have to build up mechanisms to protect themselves against oxidative stress, with enzymes such as catalase and superoxide dismutase, small proteins like thioredoxin and glutaredoxin, and molecules such as glutathione. Bacterial genetic responses to oxidative stress are controlled by two major transcriptional regulators (OxyR and SoxRS). This paper reviews major key points in the generation of reactive oxygen species in bacteria, defense mechanisms and genetic responses to oxidative stress. Special attention is paid to the oxidative damage to proteins.
Subject headings: Adaptation, Physiological; Aerobiosis; Amino Acids/chemistry; Bacteria/genetics/metabolism; Bacterial Proteins/genetics/metabolism/physiology; DNA Damage; DNA, Bacterial/genetics/metabolism; DNA-Binding Proteins; Escherichia coli Proteins; Free Radicals; Gene Expression Regulation, Bacterial; Heat-Shock Proteins/metabolism; Iron-Sulfur Proteins/metabolism; Lipid Peroxidation; Oxidation-Reduction; Oxidative Stress/genetics/physiology; Peroxides/metabolism; Reactive Oxygen Species/metabolism; Repressor Proteins/genetics/physiology; Trans-Activators; Transcription Factors/genetics/physiology; Transcription, Genetic
Publication year: 2000
Journal or book title: International Microbiology : the Official Journal of the Spanish Society for Microbiology
Volume: 3
Issue: 1
Pages: 3-8
Find the full text : https://repositori.udl.cat/bitstream/handle/10459.1/56751/001562.pdf?sequence=1
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Type: Journal Article
Serial number: 181