Synthesis and Biological Evaluation of Chalcone Derivatives (Mini Review)

Author: Nasir Abbas Bukhari, S., Jasamai, M., & Jantan, I.

Description: Chalcones are the principal precursors for the biosynthesis of flavonoids and isoflavonoids. A three carbon a, ß-unsaturated carbonyl system constitutes chalcones. Chalcones are the condensation products of aromatic aldehyde with acetophenones in attendance of catalyst. They go through an assortment of chemical reactions and are found advantageous in synthesis of pyrazoline, isoxazole and a variety of heterocyclic compounds. In synthesizing a range of therapeutic compounds, chalcones impart a key role. They have shown therapeutic efficacy for the treatment of various diseases. Chalcone-based derivatives have gained heed since they own simple structures, and diverse pharmacological actions. A lot of methods and schemes have been reported for the synthesis of these compounds. Amongst all, Aldol condensation and Claisen-Schmidt condensation still grasp a high position. Other distinguished techniques include Suzuki reaction, Witting reaction, Friedel-Crafts acylation with cinnamoyl chloride, Photo-Fries rearrangement of phenyl cinnamates, etc. These inventive techniques utilize various catalysts and reagents including SOCl2 natural phosphate, lithium nitrate, amino grafted zeolites, zinc oxide, water, Na2CO3, PEG400, silicasulfuric acid, ZrCl4 and ionic liquid, etc. The development of better techniques for the synthesis of a, ß- unsaturated carbonyl compounds is still in high demand. In brief, we have explained the methods and catalysts used in the synthesis of chalcones along with their biological activities in a review form to provide information for the development of new-fangled processes targeting better yield, less reaction time and least side effects with utmost pharmacological properties.

Subject headings: Flavonoids; Anti-inflammatory; Anticancer; Chalcones; Claisen-Schmidt condensation; Synthesis; Aldol condensation

Publication year: 2012

Journal or book title: Mini Reviews in Medicinal Chemistry

Volume: 12

Issue: 13

Pages: 1394–1403

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Type: Journal article

Serial number: 3130

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