Author: Mehta, M.; Marras, T.K.
Description: INTRODUCTION: The impact of pulmonary nontuberculous mycobacterial (pNTM) disease on health-related quality of life (HRQL) has not been quantified.
METHODS: We performed a prospective observational study of HRQL in 51 patients with pNTM disease. One generic (Short-form 36, version 2 -SF-36), and one pulmonary disease-specific instrument (St. George’s Respiratory Questionnaire–SGRQ) were administered to each subject.
RESULTS: Fifty-one patients with pNTM disease from one ambulatory clinic were enrolled. The mean (sd) age was 67 (10) years and 80% (41/51) were female. The most common causative NTM was MAC in 84% (43/51) followed by Mycobacterium abscessus in 8% (4/51). Radiographic disease type was nodular bronchiectasis in 71% (36/51) and fibrocavitary in 22% (11/51). For SF-36, most raw scores were at least 10 points below Canadian population-based normals, and all normbased scores were below the expected normal value of 50. For SGRQ, all scores were worse by >/= 25 points compared with published normals. In multivariable analyses, only FVC and DLCO were significantly associated with SF-36, and only FVC and emphysema were significantly associated with SGRQ.
CONCLUSION: Patients with pNTM disease have significantly impaired HRQL that is most closely associated with lung function and not readily explained by age, sex or extra-pulmonary comorbidity.
Subject headings: Aged; Cross-Sectional Studies; Female; Forced Expiratory Volume; Health Status; Humans; Lung Diseases/microbiology/physiopathology; Male; Mycobacterium Infections/microbiology/physiopathology; Prospective Studies; Quality of Life; Questionnaires; Severity of Illness Index; Sickness Impact Profile
Publication year: 2011
Journal or book title: Respiratory Medicine
Volume: 105
Issue: 11
Pages: 1718-1725
Find the full text : http://www.sciencedirect.com/science/article/pii/S0954611111002630
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Type: Journal Article
Serial number: 177