Of the bugs that shape us: maternal obesity, the gut microbiome, and long-term disease risk

Author: Gohir, W., Ratcliffe, E. M., & Sloboda, D. M.

Description: Chronic disease risk is inextricably linked to our early-life environment, where maternal, fetal, and childhood factors predict disease risk later in life. Currently, maternal obesity is a key predictor of childhood obesity and metabolic complications in adulthood. Although the mechanisms are unclear, new and emerging evidence points to our microbiome, where the bacterial composition of the gut modulates the weight gain and altered metabolism that drives obesity. Over the course of pregnancy, maternal bacterial load increases, and gut bacterial diversity changes and is influenced by pre-pregnancy- and pregnancy-related obesity. Alterations in the bacterial composition of the mother have been shown to affect the development and function of the gastrointestinal tract of her offspring. How these microbial shifts influence the maternal-fetal-infant relationship is a topic of hot debate. This paper will review the evidence linking nutrition, maternal obesity, the maternal gut microbiome, and fetal gut development, bringing together clinical observations in humans and experimental data from targeted animal models.

Subject headings: Female; Gastrointestinal Tract; Humans; Maternal Nutritional Physiological Phenomena; Maternal-Fetal Exchange; Microbiota; Obesity; Pregnancy; Prenatal Exposure Delayed Effects; Microbiome; Gut

Publication year: 2015

Journal or book title: Pediatric Research

Volume: 77

Issue: 1-2

Pages: 196–204

Find the full text: https://www.nature.com/articles/pr2014169

Find more like this one (cited by): https://scholar.google.com/scholar?cites=17971677944905995571&as_sdt=1000005&sciodt=0,16&hl=en

Type: Journal article

Serial number: 3136

Leave a Reply

Your email address will not be published.

This site uses Akismet to reduce spam. Learn how your comment data is processed.