Author: Jiang, D.; Peng, J.; Chen, Y.
Description: A novel route to the synthesis of Delta2-isoxazoline derivatives is described. Reaction of beta,gamma-unsaturated oximes with aryl bromides via palladium-catalyzed carboetherification affords 3,5-disubstituted Delta2-isoxazolines in good yields. The use of Xantphos as ligand is crucial for the transformation. The carboetherification products can be further converted to beta-hydroxy ketones in the presence of Fe powder and NH4Cl.
Subject headings: Catalysis; Isoxazoles/chemical synthesis/chemistry; Molecular Structure; Oximes/chemistry; Palladium/chemistry; Delta2-isoxazoline
Publication year: 2008
Journal or book title: Organic Letters
Volume: 10
Issue: 9
Pages: 1695-1698
Find the full text : https://pubs.acs.org/doi/abs/10.1021/ol8002173
Find more like this one (cited by): https://scholar.google.com/scholar?cites=6979637355406481628&as_sdt=1000005&sciodt=0,16&hl=en
Type: Journal Article
Serial number: 206