Caenorhabditis elegans ras gene let-60 acts as a switch in the pathway of vulval induction

Author: Beitel, G.J.; Clark, S.G.; Horvitz, H.R.

Description: The let-60 gene, an essential ras gene of the nematode Caenorhabditis elegans, acts as a switch in the inductive signalling pathway that initiates vulva formation. Recessive let-60 mutations that cause a vulvaless phenotype prevent let-60 function in response to the inductive signal. These mutations are clustered and define regions necessary either for the activation or for the action of the let-60 ras protein. Dominant let-60 mutations that cause a multivulva phenotype alter codon 13 and activate let-60 in vivo, rendering it independent of the inductive signal. The let-60 gene acts within an extensively defined genetic pathway, and other genes within this pathway seem likely to encode molecules that regulate let-60 function as well as molecules that are targets of let-60 action.

Subject headings: Alleles; Animals; Base Sequence; Caenorhabditis/genetics/growth & development; Chromosome Mapping; Codon; Embryonic Induction; Female; GTP-Binding Proteins/physiology; Molecular Sequence Data; Mutation; Phenotype; Proto-Oncogene Proteins p21(ras)/physiology; Signal Transduction; Vulva/embryology; C elegans

Publication year: 1990

Journal or book title: Nature

Volume: 348

Issue: 6301

Pages: 503-509

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Type: Journal Article

Serial number: 2905