High-glucose diets induce mitochondrial dysfunction in Caenorhabditis elegans

Author: Alcántar-Fernández, J., González-Maciel, A., Reynoso-Robles, R., Andrade, M. E. P., Hernández-Vázquez, A. d. J., Velázquez-Arellano, A., & Miranda-Ríos, J.

Description: Glucose is an important nutrient that dictates the development, fertility and lifespan of all organisms. In humans, a deficit in its homeostatic control might lead to hyperglucemia and the development of obesity and type 2 diabetes, which show a decreased ability to respond to and metabolize glucose. Previously, we have reported that high-glucose diets (HGD) induce alterations in triglyceride content, body size, progeny, and the mRNA accumulation of key regulators of carbohydrate and lipid metabolism, and longevity in Caenorhabditis elegans. Herein, we show that increasing amounts of glucose in the diet induce the swelling of both mitochondria in germ and muscle cells. Additionally, HGD alter the enzymatic activities of the different respiratory complexes in an intricate pattern. Finally, we observed a downregulation of ceramide synthases (hyl-1 and hyl-2) and antioxidant genes (gcs-1 and gst-4), while mitophagy genes (pink-1 and dct-1) were upregulated, probably as part of a mitohormetic mechanism in response to glucose toxicity.

Subject headings: Mitochondria; Glucose; Mitochondrial DNA; Endoplasmic reticulum; Muscle cells; Larvae; Nucleotides; Caenorhabditis elegans; C elegans

Publication year: 2019

Journal or book title: PLOS ONE

Volume: 14

Issue: 12

Pages: e0226652

Find the full text: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0226652

Find more like this one (cited by): https://scholar.google.com/scholar?cites=7425289860546620086&as_sdt=2005&sciodt=0,5&hl=en

Type: Journal article

Serial number: 3147

Leave a Reply

Your email address will not be published.

This site uses Akismet to reduce spam. Learn how your comment data is processed.