A common neural signature of brain injury in concussion and subconcussion

Author: Hirad, Adnan A.; Bazarian, Jeffrey J.; Merchant-Borna, Kian; Garcea, Frank E.; Heilbronner, Sarah; Paul, David; Hintz, Eric B.; van Wijngaarden, Edwin; Schifitto, Giovanni; Wright, David W.; Espinoza, Tamara R.; Mahon, Bradford Z.

Description: The midbrain is biomechanically susceptible to force loading from repetitive subconcussive head impacts (RSHI), is a site of tauopathy in chronic traumatic encephalopathy (CTE), and regulates functions (e.g., eye movements) often disrupted in concussion. In a prospective longitudinal design, we demonstrate there are reductions in midbrain white matter integrity due to a single season of collegiate football, and that the amount of reduction in midbrain white matter integrity is related to the amount of rotational acceleration to which players’ brains are exposed. We then replicate the observation of reduced midbrain white matter integrity in a retrospective cohort of individuals with frank concussion, and further show that variance in white matter integrity is correlated with levels of serum-based tau, a marker of blood-brain barrier disruption. These findings mean that noninvasive structural MRI of the midbrain is a succinct index of both clinically silent white matter injury as well as frank concussion.

Subject headings: Athletes; Brain; Brain Concussion; Brain Injuries; Traumatic; Case-Control Studies; Female; Football; Humans; Magnetic Resonance Imaging; Male; Mesencephalon; Spatial Analysis; White Matter; Young Adult; tau Proteins

Publication year: 2019

Journal or book title: Science Advances

Volume: 5

Issue: 8

Pages: eaau3460

Find the full text: https://advances.sciencemag.org/content/advances/5/8/eaau3460.full.pdf

Find more like this one (cited by): https://scholar.google.com/scholar?cites=15595590637196470311&as_sdt=1000005&sciodt=0,16&hl=en

Serial number: 3162

Leave a Reply

Your email address will not be published. Required fields are marked *

This site uses Akismet to reduce spam. Learn how your comment data is processed.