Author: Liang, G.; Li, X.; Chen, L.; Yang, S.; Wu, X.; Studer, E.; Gurley, E.; Hylemon, P.B.; Ye, F.; Li, Y.; Zhou, H.
Description: Curcumin has been extensively studied for its anti-inflammatory activities. However, its potential beneficial effects on various disease preventions and treatments are limited by its unstable structure. The beta-diketone moiety renders curcumin to be rapidly metabolized by aldo-keto reductase in liver. In the present study, a series of curcumin analogues with more stable chemical structures were synthesized and several compounds showed an enhanced ability to inhibit lipopolysaccharide (LPS)-induced TNF-alpha and IL-6 synthesis in macrophages.
Subject headings: Animals; Anti-Inflammatory Agents, Non-Steroidal/chemical synthesis/pharmacology; Curcumin/analogs & derivatives/chemical synthesis/pharmacology; Cyclohexanones/chemical synthesis/pharmacology; Cyclopentanes/chemical synthesis/pharmacology; Interleukin-6/biosynthesis; Lipopolysaccharides/antagonists & inhibitors/pharmacology; Macrophages/drug effects/immunology; Mice; Tumor Necrosis Factor-alpha/biosynthesis
Publication year: 2008
Journal or book title: Bioorganic & Medicinal Chemistry Letters
Volume: 18
Issue: 4
Pages: 1525-1529
Find the full text : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2268908/
Find more like this one (cited by): https://scholar.google.com/scholar?cites=8400058712896658208&as_sdt=1000005&sciodt=0,16&hl=en
Type: Journal Article
Serial number: 292