Ubiquitin-mediated regulation of apoptosis

Author: Broemer, Meike; Meier, Pascal

Description: Ubiquitin is a protein modifier that is conjugated to target proteins either as a single moiety or as polyubiquitin chains. Over the past several years, an increasing number of ubiquitin ligases and ubiquitin-deconjugating enzymes have been identified; these modulate cell survival by degradative and non-degradative means. Mutations that affect ubiquitin-mediated signalling are tightly linked to various human pathologies including tumorigenesis. Unravelling how the ubiquitin-signal is conjugated, edited and ‘read’ is crucial to understanding cellular processes such as endocytic trafficking, NF-kappaB signalling, gene expression, DNA repair and apoptosis. In this review, we summarize recent advances that start to elucidate how the ubiquitin message is used as a versatile tool to regulate apoptosis, for example in the conjugation of ubiquitin to caspases. This results in steric interference with substrate entry and allosteric conformational impairment of the catalytic pocket of the caspase.

Subject headings: Animals; Apoptosis; Humans; Ubiquitin; Ubiquitin-Protein Ligases

Publication year: 2009

Journal or book title: Trends in Cell Biology

Volume: 19

Issue: 3

Pages: 130-140

Find the full text: https://www.sciencedirect.com/science/article/abs/pii/S0962892409000282

Find more like this one (cited by): https://scholar.google.com/scholar?cites=2226799460260072800&as_sdt=5,26&sciodt=0,26&hl=en

Serial number: 3289

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