Author: Lutkenhaus, J.
Description: The positioning of a cytoskeletal element that dictates the division plane is a fundamental problem in biology. The assembly and positioning of this cytoskeletal element has to be coordinated with DNA segregation and cell growth to ensure that equal-sized progeny cells are produced, each with a copy of the chromosome. In most prokaryotes, cytokinesis involves positioning a Z ring assembled from FtsZ, the ancestral homologue of tubulin. The position of the Z ring is determined by a gradient of negative regulators of Z-ring assembly. In Escherichia coli, the Min system consists of three proteins that cooperate to position the Z ring through a fascinating oscillation, which inhibits the formation of the Z ring away from midcell. Additional gradients of negative regulators of FtsZ assembly are used by E. coli and other bacteria to achieve spatial control of Z-ring assembly.
Subject headings: Adenosine Triphosphatases/genetics/metabolism; Bacteria/cytology/metabolism; Bacterial Proteins/genetics/metabolism; Cell Cycle Proteins/genetics/metabolism; Cell Membrane/metabolism; Cytokinesis/physiology; Cytoskeleton/metabolism; Escherichia coli Proteins/genetics/metabolism; Gene Expression Regulation, Bacterial; Phenotype; Protein Binding
Publication year: 2007
Journal or book title: Annual Review of Biochemistry
Volume: 76
Pages: 539-562
Find the full text : https://www.annualreviews.org/doi/abs/10.1146/annurev.biochem.75.103004.142652
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Type: Journal Article
Serial number: 434