Author: Sobha, S.; Mahalakshmi, R.; Raman, N.
Description: A series of Cu(II), Ni(II) and Zn(II) complexes of the type ML have been synthesized with Schiff bases derived from o-acetoacetotoluidide, 2-hydroxybenzaldehyde and o-phenylenediamine/1,4-diaminobutane. The complexes are insoluble in common organic solvents but soluble in DMF and DMSO. The measured molar conductance values in DMSO indicate that the complexes are non-electrolytic in nature. All the six metal complexes have been fully characterized with the help of elemental analyses, molecular weights, molar conductance values, magnetic moments and spectroscopic data. The analytical data helped to elucidate the structure of the metal complexes. The Schiff bases are found to act as tetradentate ligands using N(2)O(2) donor set of atoms leading to a square-planar geometry for the complexes around all the metal ions. The binding properties of metal complexes with DNA were investigated by absorption spectra, viscosity measurements and cyclic voltammetry. Detailed analysis reveals that the metal complexes intercalate into the DNA base stack as intercalators. All the metal complexes cleave the pUC19 DNA in presence of H(2)O(2.) The Schiff bases and their complexes have been screened for their antibacterial activity against five bacterial strains (Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Staphylococcus epidermidis, Klebsiella pneumoniae) by disk diffusion method. All the metal complexes have potent biocidal activity than the free ligands.
Subject headings: Animals; Anti-Bacterial Agents–chemistry, pharmacology; Bacteria–drug effects; Bacterial Infections–drug therapy; Cattle; Coordination Complexes–chemistry, pharmacology; DNA–metabolism; Intercalating Agents–chemistry, pharmacology; Microbial Sensitivity Tests; Nitrous Oxide–chemistry; Schiff Bases–chemistry, pharmacology; Spectrum Analysis; Transition Elements–chemistry, pharmacology
Publication year: 2012
Journal or book title: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Volume: 92
Issue:
Pages: 175-183
Find the full text : https://www.sciencedirect.com/science/article/pii/S1386142512001801
Find more like this one (cited by): https://scholar.google.com/scholar?cites=14514735975677007466&as_sdt=1000005&sciodt=0,16&hl=en
Type: Journal Article
Serial number: 449