Chronic infusion of nicotine can increase operant self-administration of alcohol

Author: Clark, A.; Lindgren, S.; Brooks, S. P.; Watson, W. P.; Little, H. J.

Description: Effects of nicotine, administered by continuous infusion via osmotic minipumps, were studied on the operant self-administration of alcohol by rats, using a variable interval (15 s) schedule, and measuring the acquisition, maintenance, extinction and reinstatement of responding for alcohol. Doses of nicotine of 0.25, 1.25 and 7.5 mg/kg/24 h had no significant effects on the maintenance of responding for alcohol, but 5 mg/kg/24 h nicotine resulted in a significant increase in responding on the lever delivering the reward when water was substituted for the alcohol, indicating delayed extinction of responding. During infusion of 2.5 mg/kg/24 h nicotine, responding was significantly greater over the sucrose-fading training sessions, during acquisition of responding, when mixtures of alcohol and sucrose were provided as reward. When minipumps infusing 2.5 mg/kg/24 h nicotine were implanted after the alcohol responding had been acquired, the responding for alcohol increase during the first week of nicotine infusion, but corresponding nicotine infusion doses of 0.25, 1.25 and 7.5 had no significant effects. The results indicate that nicotine can increase operant responding for alcohol and this is crucially dependent on the dose of nicotine and the time of testing. The results have implications for the frequently encountered dependence on the combination of alcohol and nicotine.

Subject headings: Alcohol Drinking; Animals; Central Nervous System Depressants; Conditioning, Operant; Ethanol; Infusion Pumps; Implantable; Male; Nicotine; Nicotinic Agonists; Rats; Reinforcement Schedule

Publication year: 2001

Journal or book title: Neuropharmacology

Volume: 41

Issue: 1

Pages: 108-117

Find the full text:

Find more like this one (cited by):,26&sciodt=0,26&hl=en

Serial number: 3325

Leave a Reply

Your email address will not be published. Required fields are marked *

This site uses Akismet to reduce spam. Learn how your comment data is processed.