Author: Ruff, William E.; Kriegel, Martin A.
Description: The microbiota is considered to be an important factor influencing the pathogenesis of autoimmunity at both barrier sites and internal organs. Impinging on innate and adaptive immunity, commensals exert protective or detrimental effects on various autoimmune animal models. Human microbiome studies of autoimmunity remain largely descriptive, but suggest a role for dysbiosis in autoimmune disease. Humanized gnotobiotic approaches have advanced our understanding of immune-commensal interactions, but little is known about the mechanisms in autoimmunity. We propose that, similarly to infectious agents, the microbiota mediates autoimmunity via bystander activation, epitope spread, and, particularly under homeostatic conditions, via crossreactivity. This review presents an overview of the current literature concluding with outstanding questions in this field.
Subject headings: Adaptive Immunity; Animals; Autoimmune Diseases; Autoimmunity; Disease Models; Animal; Homeostasis; Host-Pathogen Interactions; Humans; Inflammatory Bowel Diseases; Intestines; Microbiota; Bystander activation; Commensal; Crossreactivity; Epitope spread; Microbiome; Molecular mimicry
Publication year: 2015
Journal or book title: Trends in Molecular Medicine
Volume: 21
Issue: 4
Pages: 233-244
Find the full text: https://www.strategian.com/fulltext/Ruff2015.pdf
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Serial number: 3331