Author: Islas-Jacome, Alejandro; Gonzalez-Zamora, Eduardo; Gamez-Montano, Rocio
Description: A series of tetrahydroisoquinolin-pyrrolopyridinones were prepared from an easily accessible aldehyde, a commercially available amine, a readily isolable isonitrile, and maleic anhydride via a triple process: Ugi-3CR-aza Diels-Alder/S-oxidation/Pummerer. The combination of a multicomponent Ugi-type reaction with other post-functionalization processes provides a powerful tool for the preparation of fused polyheterocyclic compounds.
Subject headings: Microwave-assisted synthesis; Tetrahydroisoquinolin-pyrrolopyridinones; Ugi-3CR; Aza Diels-Alder cycloaddition; S-oxidation; Pummerer cyclization
Publication year: 2011
Journal or book title: Tetrahedron Letters
Volume: 52
Issue: 41
Pages: 5245-5248
Find the full text: https://www.sciencedirect.com/science/article/pii/S004040391101272X
Find more like this one (cited by): https://scholar.google.com/scholar?cites=4816709459494476133&as_sdt=5,26&sciodt=0,26&hl=en
Serial number: 3346