A short microwave-assisted synthesis of tetrahydroisoquinolin-pyrrolopyridinones by a triple process: Ugi-3CR–aza Diels-Alder/S-oxidation/Pummerer

Author: Islas-Jacome, Alejandro; Gonzalez-Zamora, Eduardo; Gamez-Montano, Roci­o

Description: A series of tetrahydroisoquinolin-pyrrolopyridinones were prepared from an easily accessible aldehyde, a commercially available amine, a readily isolable isonitrile, and maleic anhydride via a triple process: Ugi-3CR-aza Diels-Alder/S-oxidation/Pummerer. The combination of a multicomponent Ugi-type reaction with other post-functionalization processes provides a powerful tool for the preparation of fused polyheterocyclic compounds.

Subject headings: Microwave-assisted synthesis; Tetrahydroisoquinolin-pyrrolopyridinones; Ugi-3CR; Aza Diels-Alder cycloaddition; S-oxidation; Pummerer cyclization

Publication year: 2011

Journal or book title: Tetrahedron Letters

Volume: 52

Issue: 41

Pages: 5245-5248

Find the full text: https://www.sciencedirect.com/science/article/pii/S004040391101272X

Find more like this one (cited by): https://scholar.google.com/scholar?cites=4816709459494476133&as_sdt=5,26&sciodt=0,26&hl=en

Serial number: 3346

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