Author: Gibson, Greg
Description: Although susceptibility loci identified through genome-wide association studies (GWAS) typically explain only a small proportion of the heritability, a classical quantitative genetic analysis now argues that considering together all common SNPs can explain a large proportion of the heritability of these complex traits. A related study provides recommendations for the sample sizes needed in future GWAS to identify additional susceptibility loci.
Subject headings: Body Height; Breast Neoplasms; Colorectal Neoplasms; Crohn Disease; Female; Gene Frequency; Genetic Predisposition to Disease; Genome-Wide Association Study; Genotype; Humans; Male; Polymorphism; Single Nucleotide; Prostatic Neoplasms
Publication year: 2010
Journal or book title: Nature Genetics
Volume: 42
Issue: 7
Pages: 558-560
Find the full text: https://www.nature.com/articles/ng0710-558
Find more like this one (cited by): https://scholar.google.com/scholar?cites=10195354380070151405&as_sdt=1000005&sciodt=0,16&hl=en
Serial number: 3351