Author: Alexandre, Francois-Rene; Pantaleone, David P.; Taylor, Paul P.; Fotheringham, Ian G.; Ager, David J.; Turner, Nicholas J.
Description: The deracemisation of dl-a-amino acids using l-amino acid oxidase from Proteus myxofaciens and amine-boranes as chemical reducing agents has been investigated. Amine-boranes were found to be of particular interest in terms of reactivity and chemoselectivity compared to sodium borohydride and cyanoborohydride. Starting from the racemate, a range of d-amino acids were obtained in yields of up to 90% and e.e.>99%.
Subject headings: Amine-borane; Amino acid; Amino acid oxidase; Deracemisation
Publication year: 2002
Journal or book title: Tetrahedron Letters
Volume: 43
Issue: 4
Pages: 707-710
Find the full text: https://www.sciencedirect.com/science/article/pii/S004040390102233X
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Serial number: 3355