Interaction of benznidazole reactive metabolites with nuclear and kinetoplastic DNA, proteins and lipids from Trypanosoma cruzi

Author: Diaz de Toranzo, E.G.; Castro, J.A.; Franke de Cazzulo, B.M.; Cazzulo, J.J.

Description: Epimastigotes of Trypanosoma cruzi (Tulahuen strain Tul 0 stock) biotransform benznidazole (N-benzyl-2-nitro-1-imidazole acetamide) to reactive metabolites that bind covalently to DNA, proteins and lipids of the parasite. These effects might be related to the trypanocidal action of benznidazole, a chemotherapeutic agent against Chagas’ disease.

Subject headings: Animals; Cell Nucleus/analysis; DNA/metabolism; Lipid Metabolism; Nitroimidazoles/metabolism; Proteins/metabolism; Trypanosoma cruzi/analysis

Publication year: 1988

Journal or book title: Experientia

Volume: 44

Issue: 10

Pages: 880-881

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Type: Journal Article

Serial number: 556