Author: Diaz de Toranzo, E.G.; Castro, J.A.; Franke de Cazzulo, B.M.; Cazzulo, J.J.
Description: Epimastigotes of Trypanosoma cruzi (Tulahuen strain Tul 0 stock) biotransform benznidazole (N-benzyl-2-nitro-1-imidazole acetamide) to reactive metabolites that bind covalently to DNA, proteins and lipids of the parasite. These effects might be related to the trypanocidal action of benznidazole, a chemotherapeutic agent against Chagas’ disease.
Subject headings: Animals; Cell Nucleus/analysis; DNA/metabolism; Lipid Metabolism; Nitroimidazoles/metabolism; Proteins/metabolism; Trypanosoma cruzi/analysis
Publication year: 1988
Journal or book title: Experientia
Volume: 44
Issue: 10
Pages: 880-881
Find the full text : https://link.springer.com/article/10.1007/BF01941187
Find more like this one (cited by): https://scholar.google.com/scholar?cites=15620116559272300070&as_sdt=1000005&sciodt=0,16&hl=en
Type: Journal Article
Serial number: 556