Author: Wang, Zhichao; Wang, Qiong A.; Liu, Yong; Jiang, Lei
Description: Brown adipose tissue (BAT) is well known to burn calories through uncoupled respiration, producing heat to maintain body temperature. This ‘calorie wasting’ feature makes BAT a special tissue, which can function as an ‘energy sink’ in mammals. While a combination of high energy intake and low energy expenditure is the leading cause of overweight and obesity in modern society, activating a safe ‘energy sink’ has been proposed as a promising obesity treatment strategy. Metabolically, lipids and glucose have been viewed as the major energy substrates in BAT, while succinate, lactate, branched-chain amino acids, and other metabolites can also serve as energy substrates for thermogenesis. Since the cataplerotic and anaplerotic reactions of these metabolites interconnect with each other, BAT relies on its dynamic, flexible, and complex metabolism to support its special function. In this review, we summarize how BAT orchestrates the metabolic utilization of various nutrients to support thermogenesis and contributes to whole-body metabolic homeostasis.
Subject headings: Brown adipose tissue; Glucose metabolism; Metabolic flux; Obesity; Thermogenesis; Fat
Publication year: 2021, May 24
Journal or book title: The FEBS journal
Find the full text: https://www.strategian.com/fulltext/Wang2021.pdf
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Serial number: 3400