Author: Luxton, G.W.G.; Starr, D.A.
Description: Nuclear-cytoskeletal connections are central to fundamental cellular processes, including nuclear positioning and chromosome movements in meiosis. The cytoskeleton is coupled to the nucleoskeleton through conserved KASH-SUN bridges, or LINC complexes, that span the nuclear envelope. KASH proteins localize to the outer nuclear membrane where they connect the nucleus to the cytoskeleton. New findings have expanded the functional diversity of KASH proteins, showing that they interact with microtubule motors, actin, intermediate filaments, a nonconventional myosin, RanGAP, and each other. The role of KASH proteins in cellular mechanics is discussed. Genetic mutations in KASH proteins are associated with autism, hearing loss, cancer, muscular dystrophy and other diseases.
Subject headings: Animals; Cell Cycle Proteins/genetics/metabolism; Cell Nucleus/genetics/metabolism; Cytoplasm/metabolism; Humans; Kinesin/metabolism; Nuclear Proteins/genetics/metabolism; Protein Binding
Publication year: 2014
Journal or book title: Current Opinion in Cell Biology
Volume: 28
Pages: 69-75
Find the full text : https://www.sciencedirect.com/science/article/pii/S0955067414000271
Find more like this one (cited by): https://scholar.google.com/scholar?cites=10984497843360531977&as_sdt=1000005&sciodt=0,16&hl=en
Type: Journal Article
Serial number: 941