Author: Linden, D.J.
Description: A generally accepted hypothesis in neurobiology has been that at the cellular level, memories are stored, at least in part, as long-term alterations in the strength of synaptic tranmission. In recent years, considerable attention has been paid to persistent, use-dependent mechanisms that increase synaptic strength, which are collectively referred to as long-term potentiation (LTP). This review shall examine the opposite phenomenon, use-dependent decreases in synaptic strength, or long-term depression (LTD). LTD is a broad term that is used to describe synaptic depression according to several different learning rules and in a wide variety of brain structures.
Subject headings: Animals; Brain/physiology; Cerebellum/physiology; Humans; Learning/physiology; Long-Term Potentiation; Mammals; Synapses/physiology; Time Factors
Publication year: 1994
Journal or book title: Neuron
Volume: 12
Issue: 3
Pages: 457-472
Find the full text : http://www.sciencedirect.com/science/article/pii/0896627394902054
Find more like this one (cited by): https://scholar.google.com/scholar?cites=13913392663534363450&as_sdt=400005&sciodt=0,14&hl=en
Type: Journal Article
Serial number: 948