Cancer as an evolutionary and ecological process

Author: Merlo, L.M.F.; Pepper, J.W.; Reid, B.J.; Maley, C.C.

Description: Neoplasms are microcosms of evolution. Within a neoplasm, a mosaic of mutant cells compete for space and resources, evade predation by the immune system and can even cooperate to disperse and colonize new organs. The evolution of neoplastic cells explains both why we get cancer and why it has been so difficult to cure. The tools of evolutionary biology and ecology are providing new insights into neoplastic progression and the clinical control of cancer.

Subject headings: Animals; Cell Communication; Cell Proliferation; Cell Survival; Cell Transformation, Neoplastic/genetics/pathology; Disease Progression; Drug Resistance, Neoplasm/genetics; Evolution, Molecular; Gene Expression Regulation, Neoplastic; Genetic Drift; Humans; Models, Genetic; Mutation; Neoplasm Invasiveness; Neoplasms/genetics; Neoplastic Stem Cells/pathology; Selection, Genetic

Keywords: Cancer as an evolutionary and ecological process

Subject headings:

Publication year: 2006

Journal or book title: Nature Reviews. Cancer

Volume: 6

Issue: 12

Pages: 924-935

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Type: Journal Article

Serial number: 2997