Author: Blair, J.M.A.; Webber, M.A.; Baylay, A.J.; Ogbolu, D.O.; Piddock, L.J.V.
Description: Antibiotic-resistant bacteria that are difficult or impossible to treat are becoming increasingly common and are causing a global health crisis. Antibiotic resistance is encoded by several genes, many of which can transfer between bacteria. New resistance mechanisms are constantly being described, and new genes and vectors of transmission are identified on a regular basis. This article reviews recent advances in our understanding of the mechanisms by which bacteria are either intrinsically resistant or acquire resistance to antibiotics, including the prevention of access to drug targets, changes in the structure and protection of antibiotic targets and the direct modification or inactivation of antibiotics.
Subject headings: Anti-Bacterial Agents/metabolism/pharmacology; Bacteria/drug effects/metabolism/pathogenicity; Drug Resistance, Bacterial; Signal Transduction
Publication year: 2015
Journal or book title: Nature Reviews. Microbiology
Volume: 13
Issue: 1
Pages: 42-51
Find the full text: https://www.ars.usda.gov/alternativestoantibiotics/PDF/publications/MolMechAntibiotResistNRM2014.pdf
Find more like this one (cited by): https://scholar.google.com/scholar?cites=16988466264861984617&as_sdt=1000005&sciodt=0,16&hl=en
Type: Journal Article
Serial number: 1136