Protective Effects from the Ischemic/Hypoxic Stress Induced by Labor in the High-Altitude Tibetan Placenta

Author: Tana, Wuren; Noryung, Tenzing; Burton, Graham J.; van Patot, Martha Tissot; Ri-Li, Ge

Description: Labor and vaginal delivery cause acute ischemic/hypoxic insult to the placenta. Previous studies demonstrate that placentas from high altitude non-natives showed blunted responses to ischemic/hypoxic insult caused by labor and vaginal birth, and there were some differences in the ATP/ADP production ratio. We hypothesized that adapted highlanders would not have a stress response to the acute hypoxia/ischemia of labor. Tibetan laboring (n = 10) and non-laboring (n = 5) and European descendants laboring (n = 10) and non-laboring (n = 5) high-altitude placentas were analyzed using genome-wide expression array analysis. There was no evidence for ischemic/hypoxic stress in high-altitude Tibetan laboring as compared with non-laboring placentas, while there were differences in gene expression between laboring and non-laboring placentas from high-altitude European descendants. Our results provide evidence for adaptation to acute hypoxic ischemic insult caused by labor and vaginal birth in placentas in a high-altitude native Tibetan population.

Subject headings: Acclimatization; Altitude; Altitude Sickness; Female; Gene Expression Profiling; Gene Expression Regulation; Genome-Wide Association Study; Humans; Ischemia; Labor; Obstetric; Oligonucleotide Array Sequence Analysis; Parturition; Placenta; Placental Circulation; Pregnancy; Tibet; Transcriptome; High altitude; Labor; Tibetan

Publication year: 2021

Journal or book title: Reproductive Sciences

Volume: 28

Issue: 3

Pages: 659-664

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Serial number: 3536

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