Author: Flores-Mireles, A.L.; Walker, J.N.; Caparon, M.; Hultgren, S.J.
Description: Urinary tract infections (UTIs) are a severe public health problem and are caused by a range of pathogens, but most commonly by Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Enterococcus faecalis and Staphylococcus saprophyticus. High recurrence rates and increasing antimicrobial resistance among uropathogens threaten to greatly increase the economic burden of these infections. In this Review, we discuss how basic science studies are elucidating the molecular details of the crosstalk that occurs at the host-pathogen interface, as well as the consequences of these interactions for the pathophysiology of UTIs. We also describe current efforts to translate this knowledge into new clinical treatments for UTIs.
Subject headings: Anti-Bacterial Agents/therapeutic use; Bacterial Infections/drug therapy/economics/epidemiology/microbiology; Humans; Risk Factors; Urinary Tract Infections/drug therapy/economics/epidemiology/microbiology
Publication year: 2015
Journal or book title: Nature Reviews. Microbiology
Volume: 13
Issue: 5
Pages: 269-284
Find the full text : https://www.nature.com/articles/nrmicro3432
Find more like this one (cited by): https://scholar.google.com/scholar?cites=12303867275094232888&as_sdt=1000005&sciodt=0,16&hl=en
Type: Journal Article
Serial number: 1181