Integrins as therapeutic targets: lessons and opportunities

Author: Cox, D.; Brennan, M.; Moran, N.

Description: The integrins are a large family of cell adhesion molecules that are essential for the regulation of cell growth and function. The identification of key roles for integrins in a diverse range of diseases, including cancer, infection, thrombosis and autoimmune disorders, has revealed their substantial potential as therapeutic targets. However, so far, pharmacological inhibitors for only three integrins have received marketing approval. This article discusses the structure and function of integrins, their roles in disease and the chequered history of the approved integrin antagonists. Recent advances in the understanding of integrin function, ligand interaction and signalling pathways suggest novel strategies for inhibiting integrin function that could help harness their full potential as therapeutic targets.

Subject headings: Animals; Drug Delivery Systems/methods/trends; Humans; Integrins/antagonists & inhibitors/chemistry/physiology; Neoplasms/drug therapy/metabolism; Structure-Activity Relationship

Publication year: 2010

Journal or book title: Nature Reviews. Drug Discovery

Volume: 9

Issue: 10

Pages: 804-820

Find the full text: https://repository.rcsi.com/articles/journal_contribution/Integrins_as_therapeutic_targets_lessons_and_opportunities_/10782461/files/19295843.pdf

Find more like this one (cited by): https://scholar.google.com/scholar?cites=17881995201063627771&as_sdt=1000005&sciodt=0,16&hl=en

Type: Journal Article

Serial number: 1190