Author: Maines, M.D.
Description: The celebrated status of the simple gas molecule nitric oxide (NO) as the 1992 “molecule of the year” and a neuronal messenger is attributable to a complex and biologically versatile molecule, heme (Fe—protoporphyrin IX), specifically the heme prosthetic moiety of the soluble guanylate cyclase. Binding of NO to the heme moiety activates guanylate cyclase to produce cGMP, an intracellular signal molecule. In this review, evidence based on (a) the chemical interactions of carbon monoxide with the heme molecule; (b) colocalization of guanylate cyclase and cGMP with heme oxygenase isozymes, the enzyme system that produces CO; (c) the correlative relationship between heme oxygenase activity and cGMP levels; and (d) reports on the ability of CO to modulate cGMP levels in systemic organ preparations, has been marshalled to suggest that CO is a likely messenger in the brain.
Subject headings: Carbon Monoxide; CO; Heme; cGMP; Brain; Messenger
Publication year: 1993
Journal or book title: Molecular and Cellular Neurosciences
Volume: 4
Issue: 5
Pages: 389-397
Find the full text : https://www.sciencedirect.com/science/article/pii/S1044743183710493
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Type: Journal Article
Serial number: 1207