Author: Kolch, Walter
Description: The pathway from Ras through Raf and MEK (MAPK and ERK kinase) to ERK/MAPK (extracellular signal-regulated kinase/mitogen-activated protein kinase) regulates many fundamental cellular processes. Recently, a number of scaffolding proteins and endogenous inhibitors have been identified, and their important roles in regulating signaling through this pathway are now emerging. Some scaffolds augment the signal flux, but also mediate crosstalk with other pathways; certain adaptors target MEK-ERK/MAPK complexes to subcellular localizations; others provide regulated inhibition. Computational modelling indicates that, together, these modulators can determine the dynamic biological behavior of the pathway.
Subject headings: Adaptor Proteins; Signal Transducing; Animals; Drosophila Proteins; Extracellular Signal-Regulated MAP Kinases; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase Kinases; Protein Kinases; Proto-Oncogene Proteins c-raf; Ras Proteins
Publication year: 2005
Journal or book title: Nature Reviews. Molecular Cell Biology
Volume: 6
Issue: 11
Pages: 827-837
Find the full text: https://homepages.inf.ed.ac.uk/stg/papers/SIGNAL/CDGH06/resources/Kolch2005.pdf
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Serial number: 3548