Coordinating ERK/MAPK signaling through scaffolds and inhibitors

Author: Kolch, Walter

Description: The pathway from Ras through Raf and MEK (MAPK and ERK kinase) to ERK/MAPK (extracellular signal-regulated kinase/mitogen-activated protein kinase) regulates many fundamental cellular processes. Recently, a number of scaffolding proteins and endogenous inhibitors have been identified, and their important roles in regulating signaling through this pathway are now emerging. Some scaffolds augment the signal flux, but also mediate crosstalk with other pathways; certain adaptors target MEK-ERK/MAPK complexes to subcellular localizations; others provide regulated inhibition. Computational modelling indicates that, together, these modulators can determine the dynamic biological behavior of the pathway.

Subject headings: Adaptor Proteins; Signal Transducing; Animals; Drosophila Proteins; Extracellular Signal-Regulated MAP Kinases; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase Kinases; Protein Kinases; Proto-Oncogene Proteins c-raf; Ras Proteins

Publication year: 2005

Journal or book title: Nature Reviews. Molecular Cell Biology

Volume: 6

Issue: 11

Pages: 827-837

Find the full text: https://homepages.inf.ed.ac.uk/stg/papers/SIGNAL/CDGH06/resources/Kolch2005.pdf

Find more like this one (cited by): https://scholar.google.com/scholar?cites=17051526389356791678&as_sdt=1000005&sciodt=0,16&hl=en

Serial number: 3548

Leave a Reply

Your email address will not be published. Required fields are marked *

This site uses Akismet to reduce spam. Learn how your comment data is processed.