The probability of neurotransmitter release: variability and feedback control at single synapses

Author: Branco, T.; Staras, K.

Description: Information transfer at chemical synapses occurs when vesicles fuse with the plasma membrane and release neurotransmitter. This process is stochastic and its likelihood of occurrence is a crucial factor in the regulation of signal propagation in neuronal networks. The reliability of neurotransmitter release can be highly variable: experimental data from electrophysiological, molecular and imaging studies have demonstrated that synaptic terminals can individually set their neurotransmitter release probability dynamically through local feedback regulation. This local tuning of transmission has important implications for current models of single-neuron computation.

Subject headings: Animals; Feedback, Physiological/physiology; Humans; Neurons/physiology; Neurotransmitter Agents/metabolism; Probability; Synapses/physiology; Synaptic Transmission/physiology

Publication year: 2009

Journal or book title: Nature Reviews. Neuroscience

Volume: 10

Issue: 5

Pages: 373-383

Find the full text : https://www.nature.com/articles/nrn2634

Find more like this one (cited by): https://scholar.google.com/scholar?cites=17420265832024866453&as_sdt=1000005&sciodt=0,16&hl=en

Type: Journal Article

Serial number: 1322