Author: Delcour, A.H.
Description: To date most antibiotics are targeted at intracellular processes, and must be able to penetrate the bacterial cell envelope. In particular, the outer membrane of gram-negative bacteria provides a formidable barrier that must be overcome. There are essentially two pathways that antibiotics can take through the outer membrane: a lipid-mediated pathway for hydrophobic antibiotics, and general diffusion porins for hydrophilic antibiotics. The lipid and protein compositions of the outer membrane have a strong impact on the sensitivity of bacteria to many types of antibiotics, and drug resistance involving modifications of these macromolecules is common. This review will describe the molecular mechanisms for permeation of antibiotics through the outer membrane, and the strategies that bacteria have deployed to resist antibiotics by modifications of these pathways.
Subject headings: Anti-Bacterial Agents/metabolism; Bacterial Outer Membrane Proteins/metabolism; Cell Membrane Permeability/genetics/physiology; Drug Resistance, Microbial/genetics; Gram-Negative Bacteria/genetics/metabolism; Lipopolysaccharides/physiology; Porins/chemistry/metabolism
Publication year: 2009
Journal or book title: Biochimica et Biophysica Acta
Volume: 1794
Issue: 5
Pages: 808-816
Find the full text: https://www.strategian.com/fulltext/Delcour2009.pdf
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Type: Journal Article
Serial number: 1539