Author: Bennett, J.W.; Bentley, R.
Description: S. marcescens has played an important role in the history of bacterial taxonomy, in research on the transmission of bacterial aerosols, in the study of emerging nosocomial infections, and in the understanding of secondary metabolite biosynthesis. The prodigiosin pigments have intrigued organic chemists and pharmacologists, and play roles in the treatment of infectious diseases such as malaria, and perhaps as immunosuppressant agents. Undecylprodiginine played an important role in the first cloning of a gene, playing a defined role in the biosynthesis of an antibiotic. An O-methyltransferase gene was isolated by complementation and the color of undecylprodiginine was used as the selectable phenotype. The regulation of prodigiosin biosynthesis is complex, being influenced by increased glucose levels and decreased by increased phosphate level. The antibiotic resistance of many strains of S. marcescens is a serious problem with rapid horizontal transfer of drug resistance by plasmids.
Subject headings: Bacteriology/history; Bread/microbiology; History, 18th Century; History, 19th Century; History, 20th Century; Pigments, Biological/chemistry/history/metabolism/pharmacology; Prodigiosin/chemistry/metabolism/pharmacology; Serratia marcescens/chemistry/metabolism
Publication year: 2000
Journal or book title: Advances in Applied Microbiology
Volume: 47
Issue:
Pages: 1-32
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Type: Journal Article
Serial number: 1639