Author: Cockburn, I.A.; Zavala, F.
Description: Due to the diverse roles T cells play in protection against malaria as well as pathogenesis it is critical to know which cells present antigen and the nature of the antigens they present. During pre-erythrocytic stages of infection, cutting-edge imaging studies have shown how Plasmodium antigens are presented during both the priming and effector phases of the protective CD8+ T cell response. During blood stages, pathology is in part due to the loss of DC function and the action of pathogenic T cells in the brain. Recently endothelial cells presenting malaria antigen to cognate T cells have emerged as critical players in malaria pathogenesis. Manipulating these processes may inform both vaccine design and the development of therapies for cerebral malaria.
Subject headings: T cells; Malaria; Antigen; Plasmodium; Endothelial cells; Vaccine
Publication year: 2016
Journal or book title: Current Opinion in Immunology
Volume: 40
Issue:
Pages: 1-6
Find the full text :Â https://www.sciencedirect.com/science/article/pii/S0952791516000224
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Type: Journal Article
Serial number: 1688