Author: Stevenson, L.; Pimlott, S.L.; Sutherland, A.
Description: A new synthesis of the peripheral benzodiazepine receptor ligand, PK11195 has been developed in only six-steps using a Heck-type reaction and a Suzuki coupling to effect the key transformations. The flexibility of this new approach is demonstrated by the synthesis of an iodo-analogue of PK11195 prepared from the corresponding bromide using a copper catalysed aromatic Finkelstein reaction.
Subject headings: Finkelstein reaction; Receptor ligand; PK11195
Publication year: 2007
Journal or book title: Tetrahedron Letters
Volume: 48
Issue: 40
Pages: 7137-7139
Find the full text : http://www.sciencedirect.com/science/article/pii/S004040390701533X
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Type: Journal Article
Serial number: 787