Author: Harley, C.B.; Kim, N.W.; Prowse, K.R.; Weinrich, S.L.; Hirsch, K.S.; West, M.D.; Bacchetti, S.; Hirte, H.W.; Counter, C.M.; Greider, C.W.
Description: An important hallmark of cancer is aberrant growth control. Genetic changes that confer a growth advantage to the tumor cell are observed on numerous levels. Some of the best understood are mutations in proto-oncogenes and tumor suppressor genes that are linked to signal transduction pathways, cell cycle control, or cell-cell/cell-matrix interactions that regulate growth, movement, differentiation, survival, apoptosis, and genetic stability (Hartwell 1992; Weinberg 1992; Hunter 1993; Runger et al. 1994; Workman 1994). However, in addition to aberrant growth control, many cancer cells possess another important feature which distinguishes them from normal somatic cells: unlimited replicative capacity.
Hayflick first described the limited replicative capacity of normal human fibroblasts more than 30 years ago (for review, see Hayflick 1965; Goldstein 1990). Since then, numerous other somatic cell types, including epithelial cells, endothelial cells, myoblasts, astrocytes, and lymphocytes, have also shown evidence of a mitotic clock which limits their division capacity
Subject headings: Antineoplastic Agents/therapeutic use; Cell Aging; Cell Transformation, Neoplastic; DNA Replication; Enzyme Inhibitors/therapeutic use; Female; Humans; Male; Models, Biological; Neoplasms/drug therapy/enzymology/etiology; Phenotype; Telomerase/antagonists & inhibitors/metabolism
Publication year: 1994
Journal or book title: Cold Spring Harbor Symposia on Quantitative Biology
Volume: 59
Issue:
Pages: 307-315
Find the full text :Â http://symposium.cshlp.org/content/59/307.short
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Type: Journal Article
Serial number: 1731