Author: Ling, L.L.; Schneider, T.; Peoples, A.J.; Spoering, A.L.; Engels, I.; Conlon, B.P.; Mueller, A.; Schaberle, T.F.; Hughes, D.E.; Epstein, S.; Jones, M.; Lazarides, L.; Steadman, V.A.; Cohen, D.R.; Felix, C.R.; Fetterman, K.A.; Millett, W.P.; Nitti, A.G.; Zullo, A.M.; Chen, C.; Lewis, K.
Description: Antibiotic resistance is spreading faster than the introduction of new compounds into clinical practice, causing a public health crisis. Most antibiotics were produced by screening soil microorganisms, but this limited resource of cultivable bacteria was overmined by the 1960s. Synthetic approaches to produce antibiotics have been unable to replace this platform. Uncultured bacteria make up approximately 99% of all species in external environments, and are an untapped source of new antibiotics. We developed several methods to grow uncultured organisms by cultivation in situ or by using specific growth factors. Here we report a new antibiotic that we term teixobactin, discovered in a screen of uncultured bacteria. Teixobactin inhibits cell wall synthesis by binding to a highly conserved motif of lipid II (precursor of peptidoglycan) and lipid III (precursor of cell wall teichoic acid). We did not obtain any mutants of Staphylococcus aureus or Mycobacterium tuberculosis resistant to teixobactin. The properties of this compound suggest a path towards developing antibiotics that are likely to avoid development of resistance.
Subject headings: Animals; Anti-Bacterial Agents/biosynthesis/chemistry/isolation & purification/pharmacology; Betaproteobacteria/chemistry/genetics; Biological Products/chemistry/isolation & purification/pharmacology; Cell Wall/chemistry/drug effects/metabolism; Depsipeptides/biosynthesis/chemistry/isolation & purification/pharmacology; Disease Models, Animal; Drug Resistance, Microbial/genetics; Female; Mice; Microbial Sensitivity Tests; Microbial Viability/drug effects; Molecular Sequence Data; Multigene Family/genetics; Mycobacterium tuberculosis/cytology/drug effects/genetics; Peptidoglycan/biosynthesis; Staphylococcal Infections/drug therapy/microbiology; Staphylococcus aureus/chemistry/cytology/drug effects/genetics; Teichoic Acids/biosynthesis; Time Factors
Publication year: 2015
Journal or book title: Nature
Volume: 517
Issue: 7535
Pages: 455-459
Find the full text : https://www.nature.com/articles/nature14098
Find more like this one (cited by): https://scholar.google.com/scholar?cites=17850148824120499909&as_sdt=1000005&sciodt=0,16&hl=en
Type: Journal Article
Serial number: 1893