A Rapid Esterification by Means of Mixed Anhydride and Its Application to Large-ring Lactonization

Author: Inanaga, J.; Hirata, K.; Saeki, H.; Katsuki, T.; Yamaguchi, M.

Description: A rapid and mild esterification method using carboxylic 2,4,6-trichlorobenzoic anhydrides in the presence of 4-dimethylaminopyridine was developed. The method was also successfully applied to the synthesis of large-ring lactones, including DL-2,4,6-tridemethyl-3-deoxymethynolide.

Subject headings: Estrification; Lactones

Publication year: 1979

Journal or book title: Bulletin of the Chemical Society of Japan

Volume: 52

Issue: 7

Pages: 1989-1993

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Type: Journal Article

Serial number: 1895