Author: Brzustewicz, E.; Bryl, E.
Description: Rheumatoid arthritis (RA), as a common chronic disease leading to severe disability, requires early diagnosis and introduction of proper treatment. Deregulation in the cytokine network plays an undoubtedly crucial role in the pathogenesis of RA. The understanding of the role of cytokines in RA can be used for patients’ benefit. Technological advances had already allowed introduction of the tailor-made cytokine-targeted therapies (so far anti-TNF, anti-IL-1 and anti-IL-6) into clinical practice. This type of treatment is currently developing very fast. Moreover, cytokines are considered to be potential powerful biomarkers of RA with roles predicted to grow in the future. Detailed understanding of the cytokine balance in RA may assist both the diagnostic process and therapy.
Subject headings: Antibodies, Monoclonal/therapeutic use; Arthritis, Rheumatoid/drug therapy/physiopathology; Biomarkers/metabolism; Cytokines/physiology; Humans; Precision Medicine; Biological treatment; Biomarker; Cytokines; Rheumatoid arthritis; bDMARD
Publication year: 2015
Journal or book title: Cytokine
Volume: 76
Issue: 2
Pages: 527-536
Find the full text :Â https://www.sciencedirect.com/science/article/pii/S1043466615300491
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Type: Journal Article
Serial number: 1914