Author: West, C.E.; Jenmalm, M.C.; Kozyrskyj, A.L.; Prescott, S.L.
Description: Microbial ecosystems cover the surface of the human body and it is becoming increasingly clear that our modern environment has profound effects on microbial composition and diversity. A dysbiotic gut microbiota has been associated with allergic diseases and asthma in cross-sectional and observational studies. In an attempt to restore this dysbiosis, probiotics have been evaluated in randomized controlled trials. Here, we review treatment and primary prevention studies, recent meta-analyses, and discuss the current understanding of the role of probiotics in this context. Many meta-analyses have shown a moderate benefit of probiotics for eczema prevention, whereas there is less evidence of a benefit for other allergic manifestations. Because of very low quality evidence and heterogeneity between studies, specific advice on the most effective regimens cannot yet be given – not even for eczema prevention. To be able to adopt results into specific recommendations, international expert organizations stress the need for well-designed studies.
Subject headings: Animals; Asthma/therapy; Humans; Hypersensitivity/therapy; Immunity, Mucosal; Meta-Analysis as Topic; Microbiota; Primary Prevention/trends; Probiotics/therapeutic use; Randomized Controlled Trials as Topic; Diversity; dysbiosis; eczema; gut microbiome; hygiene hypothesis; primary prevention; probiotic
Publication year: 2016
Journal or book title: Expert Review of Clinical Immunology
Volume: 12
Issue: 6
Pages: 625-639
Find the full text :Â https://www.tandfonline.com/doi/abs/10.1586/1744666X.2016.1147955
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Type: Journal Article
Serial number: 1932