Author: Kiernan, M.C., Vucic, S., Cheah, B.C., Turner, M.R., Eisen, A., Hardiman, O., Burrell, J.R., Zoing, M.C.
Description: Amyotrophic lateral sclerosis (ALS) is an idiopathic, fatal neurodegenerative disease of the human motor system. In this Seminar, we summarise current concepts about the origin of the disease, what predisposes patients to develop the disorder, and discuss why all cases of ALS are not the same. In the 150 years since Charcot originally described ALS, painfully slow progress has been made towards answering these questions. We focus on what is known about ALS and where research is heading—from the small steps of extending longevity, improving therapies, undertaking clinical trials, and compiling population registries to the overarching goals of establishing the measures that guard against onset and finding the triggers for this neurodegenerative disorder.
Subject headings: Amyotrophic Lateral Sclerosis/diagnosis/etiology/therapy; Environment; Genetic Predisposition to Disease; Humans; Motor Neurons/pathology/physiology; Mutation; Suicide, Assisted; Superoxide Dismutase/genetics/metabolism; Superoxide Dismutase-1; ALS
Publication year: 2011
Journal or book title: The Lancet
Volume: 377
Issue: 9769
Pages: 942-955
Find the full text: https://www.sciencedirect.com/science/article/pii/S0140673610611567
Find more like this one (cited by): https://scholar.google.com/scholar?cites=11485550074847849240&as_sdt=1000005&sciodt=0,16&hl=en
Type: Journal Article
Serial number: 2048