Author: Cottiglia, F.; Loy, G.; Garau, D.; Floris, C.; Casu, M.; Pompei, R.; Bonsignore, L.
Description: The antimicrobial activity of stems methanol extract from Daphne gnidium L. collected from Sardinia (Italy) was evaluated against 6 strains of standard and clinical isolated gram (+/-) bacteria. The antimicrobial effect on two strains of fungi was also tested. The extract in toto exhibited antibacterial activity against Bacillus lentus and Escherichia coli, but was inactive against fungi. Four coumarins (daphnetin, daphnin, acetylumbelliferone, daphnoretin) and seven flavonoids (luteolin, orientin, isoorientin, apigenin-7-O-glucoside, genkwanin, 5-O-beta-D-primeverosyl genkwanine, 2,5,7,4′-tetrahydroxyisoflavanol) present in the plant extract were also investigated against the same strains of bacteria and fungi assayed for the crude extract. The most active compounds were daphnetin, genkwanin, and 2,5,7,4′-tetrahydroxyisoflavanol.
Subject headings: Anti-Bacterial Agents; Anti-Infective Agents/pharmacology/therapeutic use; Bacillus/drug effects; Bacteria/drug effects; Coumarins/chemistry/pharmacology; Escherichia coli/drug effects; Flavonoids/chemistry/pharmacology; Fungi/drug effects; Humans; Microbial Sensitivity Tests; Phytotherapy; Plant Extracts/pharmacology/therapeutic use; Plant Stems; Thymelaeaceae
Subject headings:
Publication year: 2001
Journal or book title: Phytomedicine : International Journal of Phytotherapy and Phytopharmacology
Volume: 8
Issue: 4
Pages: 302-305
Find the full text : https://www.sciencedirect.com/science/article/pii/S0944711304700446
Find more like this one (cited by): https://scholar.google.com/scholar?cites=7629655146048367454&as_sdt=1000005&sciodt=0,16&hl=en
Type: Journal Article
Serial number: 2200