Author: Musacchio, A.; Salmon, E.D.
Description: In eukaryotes, the spindle-assembly checkpoint (SAC) is a ubiquitous safety device that ensures the fidelity of chromosome segregation in mitosis. The SAC prevents chromosome mis-segregation and aneuploidy, and its dysfunction is implicated in tumorigenesis. Recent molecular analyses have begun to shed light on the complex interaction of the checkpoint proteins with kinetochores–structures that mediate the binding of spindle microtubules to chromosomes in mitosis. These studies are finally starting to reveal the mechanisms of checkpoint activation and silencing during mitotic progression.
Subject Headings: Aneuploidy; Animals; Cell Cycle/physiology; Cell Cycle Proteins/metabolism/physiology; Genes, cdc/physiology; Humans; Kinetochores/physiology; Models, Biological; Neoplasms/etiology/genetics; Phosphotransferases/physiology; Spindle Apparatus/metabolism; Time Factors
Subject headings:
Publication year: 2007
Journal or book title: Nature Reviews. Molecular Cell Biology
Volume: 8
Issue: 5
Pages: 379-393
Find the full text :Â https://www.nature.com/articles/nrm2163
Find more like this one (cited by): https://scholar.google.com/scholar?cites=15683140366529902196&as_sdt=1000005&sciodt=0,16&hl=en
Type: Journal Article
Serial number: 2255