Author: Foley, E.A.; Kapoor, T.M.
Description: In eukaryotes, chromosome segregation during cell division is facilitated by the kinetochore, a multiprotein structure that is assembled on centromeric DNA. The kinetochore attaches chromosomes to spindle microtubules, modulates the stability of these attachments and relays the microtubule-binding status to the spindle assembly checkpoint (SAC), a cell cycle surveillance pathway that delays chromosome segregation in response to unattached kinetochores. Recent studies are shaping current thinking on how each of these kinetochore-centred processes is achieved, and how their integration ensures faithful chromosome segregation, focusing on the essential roles of kinase-phosphatase signalling and the microtubule-binding KMN protein network.
Subject Headings: Cell Division; Chromosome Segregation; Humans; Kinetochores/metabolism; M Phase Cell Cycle Checkpoints; Microtubule-Associated Proteins/metabolism; Microtubules/metabolism; Mitosis; Nuclear Proteins/metabolism; Signal Transduction; Spindle Apparatus/metabolism
Subject headings:
Publication year: 2013
Journal or book title: Nature Reviews. Molecular Cell Biology
Volume: 14
Issue: 1
Pages: 25-37
Find the full text : https://www.strategian.com/fulltext/Foley2013.pdf
Find more like this one (cited by): https://scholar.google.com/scholar?cites=15424053984711881905&as_sdt=1000005&sciodt=0,16&hl=en
Type: Journal Article
Serial number: 2256